발암물질: 두 판 사이의 차이

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| postscript = <!-- Bot inserted parameter. Either remove it; or change its value to "." for the cite to end in a ".", as necessary. -->{{inconsistent citations}}
}}</ref> 다수의 연구들은 밤교대근무와 [[유방암]]과의 연관성을 보고하였다.<ref>Schernhammer E, Schulmeister K. Melatonin and cancer risk: does light at night compromise physiologic cancer protection by lowering serum melatonin levels? Br J Cancer 2004;90:941–943.</ref><ref>Hansen J. Increased breast cancer risk among women who work predominantly at night. Epidemiology 2001; 12:74–77.</ref><ref>Hansen J. Light at night, shiftwork, and breast cancer risk.J Natl Cancer Inst 2001; 93:1513–1515.</ref><ref>Schernhammer E, Laden F, Speizer FE et al. Rotating night shifts and risk of breast cancer in women participating in the nurses' health study. J Natl Cancer Inst 2001; 93:1563–1568.</ref><ref>{{저널 인용
| url = http://jncicancerspectrum.oupjournals.org/cgi/content/full/jnci;93/20/1557?ijkey=e1472aefe9398c2c26bf8515391f5940acc05495
| title = Night Shift Work, Light at Night, and Risk of Breast Cancer
| journal = Journal of the National Cancer Institute
| volume=93 | issue=20 | year=2001 | pages =1557–1562 93
|issue = 20
| pmid = 11604479
|year = 2001
| doi = 10.1093/jnci/93.20.1557
|pages = 1557–1562
| author1 = Scott Davis
| pmid = 11604479
| author2 = Dana K. Mirick
| doi = 10.1093/jnci/93.20.1557
| author3 = Richard G. Stevens
| author1 = Scott Davis
| author-separator = ,
| author2 = Dana K. Mirick
}}</ref><ref>{{저널 인용
| author3 = Richard G. Stevens
| author-separator = ,
|확인날짜 = 2006년 03월 04일
|보존url = https://web.archive.org/web/20030812091505/http://jncicancerspectrum.oupjournals.org/cgi/content/full/jnci
|보존날짜 = 2003년 08월 12일
|깨진링크 = 예
}}</ref><ref>{{저널 인용
| url = http://jncicancerspectrum.oupjournals.org/cgi/content/full/jnci;93/20/1563?ijkey=c01d8ce29cb0ba35061db9c434a0c8e4816e70a9
| title = Rotating Night Shifts and Risk of Breast Cancer in Women Participating in the Nurses' Health Study
줄 58 ⟶ 65:
| author7 = Graham A. Colditz
| author-separator = ,
}}</ref> 빛의 노출에 의해 밤동안 만들어 져야할 [[호르몬]]인 [[멜라토닌]] 생산의 억제는 세포면역감시 정도를 낮추게 하여 암생성을 이끌게 한다. [[멜라토닌]]은 또한 [[항산화작용]]을 하기에 이것이 만들어 지지 않는다면 암발생의 확률을 높인다.<ref name="psy.ohio-state.edu">Navara KJ, Nelson RJ (2007) [http://www.psy.ohio-state.edu/nelson/documents/JPinealRes2007.pdf The dark side of light light at night: physiological, epidemiological, and ecological consequences] {{웨이백|url=http://www.psy.ohio-state.edu/nelson/documents/JPinealRes2007.pdf |date=20111214205146 }}. J. Pineal Res. 2007; 43:215–224</ref>
 
== 발암성의 기전 ==
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== 발암 전구 물질==
발암전구물질(procarcinogen)은 발암 물질의 전구체이다. [[아질산염]]은 한 예로 음식으로 섭취된다. 이것 자체로는 발암물질이 아니지만 체내에서 발암물질인 니트로사민(nitrosamine)으로 바뀌게 된다.<ref>{{웹 인용 |url=http://www.lactospore.com/glossary.htm |title=Web definitions for Procarcinogen |publisher=Lactospore.com |date= |accessdate=2010-09-22 |보존url=https://web.archive.org/web/20100927091211/http://www.lactospore.com/glossary.htm |보존날짜=2010-09-27 |깨진링크=예 }}</ref>
 
== 일반적인 발암 물질 ==
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! [[디젤]]배기가스
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*폐<ref name=PRDEE>{{웹 인용|title=IARC: DIESEL ENGINE EXHAUST CARCINOGENIC|url=http://press.iarc.fr/pr213_E.pdf|publisher=International Agency for Research on Cancer (IARC)|accessdate=2012년 6월 12일|format=Press release|quote=2012년 6월 12일 ‐‐ After a week-long meeting of international experts, the International Agency for Research on Cancer (IARC), which is part of the World Health Organization (WHO), today classified diesel engine exhaust as carcinogenic to humans (Group 1), based on sufficient evidence that exposure is associated with an increased risk for lung cancer|보존url=https://www.webcitation.org/6Ae3bCfOk?url=http://press.iarc.fr/pr213_E.pdf|보존날짜=2012년 09월 13일|깨진링크=예}}</ref>
*[[방광]]암<ref name=PRDEE />
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