코카인: 두 판 사이의 차이

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TedBot (토론 | 기여)
잔글 봇: 틀 이름 및 스타일 정리
5번째 줄:
| drug_name =
| IUPAC_name = Methyl (1''R'',2''R'',3''S'',5''S'')-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
| image = Kokain - Cocaine.svg
| image2 = Cocaine-from-xtal-1983-3D-balls.png
 
11번째 줄:
| pronounce = kəʊˈkeɪn
| Drugs.com = {{drugs.com|CONS|cocaine}}
| tradename = Neurocaine,<ref>{{cite book서적 인용|last1=Nordegren |first1=Thomas |title=The A-Z Encyclopedia of Alcohol and Drug Abuse |date=2002 |publisher=Universal-Publishers |isbn=9781581124040 |page=461 |url=https://books.google.ca/books?id=4yaGePenGKgC&pg=PA461 |language=en}}</ref> other
| pregnancy_US = C
| legal_AU = Schedule 8
18번째 줄:
| legal_NZ = Class A
| legal_UK = Class A
| legal_US = Schedule II<ref name=DEA2017Sched>{{cite web인용|title=DEA / Drug Scheduling|url=https://www.dea.gov/druginfo/ds.shtml|website=www.dea.gov|access-date=7 August 2017|deadurl=no|archive-url=https://web.archive.org/web/20170809044016/https://www.dea.gov/druginfo/ds.shtml|archive-date=9 August 2017|df=dmy-all}}</ref>
| legal_UN = N I III
| legal_status =
| dependency_liability = {{plainlist|
*[[Physical dependence|Physical]]: none<ref>{{cite book서적 인용|vauthors=Malenka RC, Nestler EJ, Hyman SE |veditors=Sydor A, Brown RY | title = Molecular Neuropharmacology: A Foundation for Clinical Neuroscience | year = 2009 | publisher = McGraw-Hill Medical | location = New York | isbn = 978-0-07-148127-4 | edition = 2nd | chapter = Chapter 15: Reinforcement and Addictive Disorders | page = 367 | quote= While physical dependence and withdrawal occur with some drugs of abuse (opiates, ethanol), these phenomena are not useful in the diagnosis of addiction because they do not occur with other drugs of abuse (cocaine, amphetamine) and can occur with many drugs that are not abused (propranolol, clonidine).}}</ref>
*[[Psychological dependence|Psychological]]: High<ref name=Gho2010>{{cite서적 book인용| first1 = Hamid | last1 = Ghodse | name-list-format = vanc | title = Ghodse's Drugs and Addictive Behaviour: A Guide to Treatment|date=2010|publisher=Cambridge University Press|isbn=978-1-139-48567-8|page=91|edition=4|url=https://books.google.com/books?id=WYQ23OMjWbcC&pg=PA91|deadurl=no|archive-url=https://web.archive.org/web/20170910234911/https://books.google.com/books?id=WYQ23OMjWbcC&pg=PA91|archive-date=10 September 2017|df=dmy-all}}</ref>}}
| addiction_liability = High<ref>{{cite서적 book인용|title=Introduction to Pharmacology Third Edition|date=2007|publisher=CRC Press|location=Abingdon|isbn=978-1-4200-4742-4|pages=222–223|url=https://books.google.com/books?id=qfrLBQAAQBAJ&pg=PA222|deadurl=no|archive-url=https://web.archive.org/web/20170910234921/https://books.google.com/books?id=qfrLBQAAQBAJ&pg=PA222|archive-date=10 September 2017|df=dmy-all}}</ref>
| routes_of_administration = [[Topical]], [[route of administration#Oral|oral]], [[insufflation (medicine)|insufflation]], [[intravenous]]
| class = {{plainlist|
32번째 줄:
<!--Pharmacokinetic data-->
| bioavailability = {{plainlist|
*[[route of administration#Oral|By mouth]]: 33%<ref name="fattinger2000">{{cite journal저널 인용| vauthors = Fattinger K, Benowitz NL, Jones RT, Verotta D | title = Nasal mucosal versus gastrointestinal absorption of nasally administered cocaine | journal = European Journal of Clinical Pharmacology | volume = 56 | issue = 4 | pages = 305–10 | date = July 2000 | pmid = 10954344 | doi = 10.1007/s002280000147 }}</ref>
*[[Insufflation (medicine)|insufflated]]: 60<ref>{{cite journal저널 인용| vauthors = Barnett G, Hawks R, Resnick R | title = Cocaine pharmacokinetics in humans | journal = Journal of Ethnopharmacology | volume = 3 | issue = 2–3 | pages = 353–66 | year = 1981 | pmid = 7242115 | doi = 10.1016/0378-8741(81)90063-5 }}</ref>–80%<ref>{{cite journal저널 인용| vauthors = Jeffcoat AR, Perez-Reyes M, Hill JM, Sadler BM, Cook CE | title = Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking | journal = Drug Metabolism and Disposition | volume = 17 | issue = 2 | pages = 153–9 | year = 1989 | pmid = 2565204 }}</ref>
*[[Nasal spray]]: 25<ref>{{cite journal저널 인용| vauthors = Wilkinson P, Van Dyke C, Jatlow P, Barash P, Byck R | title = Intranasal and oral cocaine kinetics | journal = Clinical Pharmacology and Therapeutics | volume = 27 | issue = 3 | pages = 386–94 | date = March 1980 | pmid = 7357795 | doi = 10.1038/clpt.1980.52 }}</ref>–43%<ref name="fattinger2000" />}}
| metabolism = [[liver]] [[CYP3A4]]
| metabolites = [[Norcocaine]], [[benzoylecgonine]], [[cocaethylene]]