사용자:Jotdanodb/연습장
| 번호 | 주제 |
|---|---|
| 1 | mebendazole |
| 2 | hernia |
| 3 | 치매 |
| 4 | lyme disease |
메벤다졸 (Mebendazole) 메벤다졸은 많은 기생충 감염에 쓰이는 약물이다. 회충, 요충, 구충, 메디나충, 포충, 람블편모충 등과 같은 기생충 치료에 이용된며 쥐를 통해 얻을 수 있다.
Mebendazole is usually well tolerated.[3] Common side effects include headache, vomiting, and ringing in the ears.[3] If used at large doses it may cause bone marrow suppression.[3] It is unclear if it is safe in pregnancy.[3] Mebendazole is a broad-spectrum antihelminthic agent of the benzimidazole type.[3]
Mebendazole came into use in 1971, after it was developed by Janssen Pharmaceutica in Belgium.[4] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] Mebendazole is available as a generic medication.[6] The wholesale cost in the developing world is between 0.004 and 0.04 USD per dose.[7] In the United States a single dose is about 440.00 USD as of 2016, while in Australia and the UK it costs about 5 USD.[8] Medical use[edit source]
Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations, including roundworm, hookworm, whipworm, threadworm, pinworm, and the intestinal form of trichinosis prior to its spread into the tissues beyond the digestive tract. Other drugs are used to treat worm infections outside the digestive tract, as mebendazole is poorly absorbed into the bloodstream.[9] Mebendazole is used alone in those with mild to moderate infestations. It kills parasites relatively slowly, and in those with very heavy infestations, it can cause some parasites to migrate out of the digestive system, leading to appendicitis, bile duct problems, or intestinal perforation. To avoid this, heavily infested patients may be treated with piperazine, either before or instead of mebendazole. Piperazine paralyses the parasites, causing them to pass in the feces.[10] It is also used rarely in the treatment of hydatid disease. Evidence for effectiveness for this disease, however, is poor.[11]
Mebendazole and other benzimidazole antithelmetics are active against both larval and adult stages of nematodes, and in the cases of roundworm and whipworm, kill the eggs, as well. Paralysis and death of the parasites occurs slowly, and elimination in the feces may require several days.[9]
Special populations[edit source]
Mebendazole is pregnancy category C, which means it has been shown to cause ill effects in pregnancy in animal models, and no adequate studies of its effects in human pregnancy have been conducted. Whether it can be passed by breastfeeding is unknown.[12]
Adverse effects[edit source]
Mebendazole sometimes causes diarrhea, abdominal pain, and elevated liver enzymes. In rare cases, it has been associated with a dangerously low white blood cell count, low platelet count, and hair loss,[12][13] with a risk of agranulocytosis in rare cases
Drug interactions[edit source]
Carbamazepine and phenytoin lower serum levels of mebendazole. Cimetidine does not appreciably raise serum mebendazole (in contrast to the similar drug albendazole), consistent with its poor systemic absorption.[14][15]
Stevens–Johnson syndrome and the more severe toxic epidermal necrolysis can occur when mebendazole is combined with high doses of metronidazole.[16]
Mechanism[edit source]
Mebendazole is thought to work by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubules in their intestinal cells, thereby blocking the uptake of glucose and other nutrients, resulting in the gradual immobilization and eventual death of the helminths.[9]
Society and culture[edit source]
Availability[edit source]
Mebendazole is available as a generic medication.[6] Mebendazole is distributed in international markets by Johnson and Johnson and a number of generic manufacturers.[17]
Cost[edit source]
In the developing world the wholesale cost is between 0.004 and 0.04 USD per dose as of 2014.[7] In the United States a single dose was about 18 USD in 2015.[3] In 2016 the price increased to 440.00 USD per dose in the U.S. as Amedra Pharmaceuticals acquired the rights from Teva in 2013.[8]
In 2010, Amedra also bought the U.S. Marketing rights to the only other interchangeable anti-parasitic medication, albendazole, from GSK. The result of these acquisitions created a monopoly these medications and the price increased dramatically.[18]
Research[edit source]
Several studies show mebendazole exhibits potent antitumor properties. MBZ significantly inhibited cancer cell growth, migration, and metastatic formation of adrenocortical carcinoma, both in vitro and in vivo.[19] Treatment of lung cancer cell lines with MBZ caused mitotic arrest, followed by apoptotic cell death with the feature of caspase activation and cytochrome c release.[20] MBZ induced a dose- and time-dependent apoptotic response in human lung cancer cell lines,[21] and apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells.[22]
References[edit source]
1.Jump up ^ Ebadi, Manuchair (2008). Desk reference of clinical pharmacology (2 ed.). Boca Raton: CRC Press. p. 403. ISBN 9781420047448. Archived from the original on 2017-09-08.
2.Jump up ^ "Archived copy". Archived from the original on 2016-10-23. Retrieved 2016-04-29.
3.^ Jump up to: a b c d e f g h i "Mebendazole". The American Society of Health-System Pharmacists. Archived from the original on 2015-09-07. Retrieved Aug 18, 2015.
4.Jump up ^ Mehlhorn, Heinz (2001). Encyclopedic reference of parasitology. 107 tables (2 ed.). Berlin [u.a.]: Springer. p. 259. ISBN 9783540668299. Archived from the original on 2017-09-08.
5.Jump up ^ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
6.^ Jump up to: a b Hamilton, Richard J. (2012). Tarascon pocket pharmacopoeia (13 ed.). Burlington, Mass.: Jones & Bartlett Learning. p. 33. ISBN 9781449624286. Archived from the original on 2017-09-08.
7.^ Jump up to: a b "Mebendazole". International Drug Price Indicator Guide. Archived from the original on 5 March 2017. Retrieved 18 August 2015.
8.^ Jump up to: a b Crow, David (18 December 2016). "US drugmaker charges 200 times UK price for common worm pill". www.ft.com. Archived from the original on 8 January 2017. Retrieved 8 January 2017. (Subscription required (help)).
9.^ Jump up to: a b c Petri WA in Brunton LL, Chabner BA, Knollmann BC, Ed. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 12th ed., Chapter 42. McGraw-Hill, 2011 New York.
10.Jump up ^ Martin AR in Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry, 8th edition, Doerge RF, ed. J.B. Lippincott, 1982, Chapter 4
11.Jump up ^ "Mebendazole". drugs.com. Archived from the original on 22 February 2015. Retrieved 25 January 2015.
12.^ Jump up to: a b Finberg R, Fingeroth J in Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo, Ed. Harrison's Principles of Internal Medicine, 18th ed., McGraw-Hill, 2012, Chapter 217.
13.Jump up ^ Andersohn F, Konzen C, Garbe E (May 2007). "Systematic review: agranulocytosis induced by nonchemotherapy drugs". Ann. Intern. Med. 146 (9): 657–65. doi:10.7326/0003-4819-146-9-200705010-00009. PMID 17470834. Archived from the original on 2014-01-08.
14.Jump up ^ "Drug Interactions". Medicine chest. Archived from the original on 2007-02-06. Retrieved 2008-05-06.
15.Jump up ^ Luder PJ, Siffert B, Witassek F, Meister F, Bircher J; Siffert; Witassek; Meister; Bircher (1986). "Treatment of hydatid disease with high oral doses of mebendazole. Long-term follow-up of plasma mebendazole levels and drug interactions". European Journal of Clinical Pharmacology. 31 (4): 443–448. doi:10.1007/bf00613522. PMID 3816925.
16.Jump up ^ Chen, K. T.; Twu, S. J.; Chang, H. J.; Lin, R. S. (2003). "Outbreak of Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis Associated with Mebendazole and Metronidazole Use Among Filipino Laborers in Taiwan". American Journal of Public Health. 93 (3): 489–492. doi:10.2105/ajph.93.3.489. PMC 1447769. PMID 12604501.
17.Jump up ^ Global Pharmaceutical Pricing and Reimbursement Database, zenRx Research, archived from the original on 30 June 2015, retrieved 2014-06-12
18.Jump up ^ "High-Cost Generic Drugs — Implications for Patients and Policymakers". New England Journal of Medicine. 372 (7): 685. 2015. doi:10.1056/NEJMc1415471.
19.Jump up ^ Martarelli D, Pompei P, Baldi C, Mazzoni G (April 2008). "Mebendazole inhibits growth of human adrenocortical carcinoma cell lines implanted in nude mice". Cancer Chemother. Pharmacol. 61 (5): 809–17. doi:10.1007/s00280-007-0538-0. PMID 17581752.
20.Jump up ^ Sasaki J, Ramesh R, Chada S, Gomyo Y, Roth JA, Mukhopadhyay T (November 2002). "The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells". Mol. Cancer Ther. 1 (13): 1201–9. PMID 12479701.
21.Jump up ^ Mukhopadhyay T, Sasaki J, Ramesh R, Roth JA (September 2002). "Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo". Clin. Cancer Res. 8 (9): 2963–9. PMID 12231542.
22.Jump up ^ Doudican N, Rodriguez A, Osman I, Orlow SJ (August 2008). "Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells". Mol. Cancer Res. 6 (8): 1308–15. doi:10.1158/1541-7786.MCR-07-2159. PMID 18667591.
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