생물학적 반감기: 두 판 사이의 차이

'''생물학적 반감기'''는 [[방사성 물질]]이나 [[약|약물]] 따위의 물질이 생물의 몸 속에서 절반으로 줄어드는 데 걸리는 시간이다. 일반적으로 물질의 [[혈장]] 농도가 최대혈장농도(C_max)의 절반으로 줄어드는 시간을 통해 측정하며<ref>{{웹 인용|url=https://sites.google.com/site/pharmacologyinonesemester/2-drug-distribution-metabolism-and-elimination/2-5-blood-levels/2-5-2-elimination-half-life |title=Pharmacology in one semester |access-date=20 February 2020 |archive-date=22 October 2020 |archive-url=https://web.archive.org/web/20201022081736/https://sites.google.com/site/pharmacologyinonesemester/2-drug-distribution-metabolism-and-elimination/2-5-blood-levels/2-5-2-elimination-half-life |url-status=dead }}</ref><ref name="AIDSinfo 2020">{{웹 인용| title=Half-Life (t½) Definition | website=AIDSinfo | date=2020-02-19 | url=https://aidsinfo.nih.gov/understanding-hiv-aids/glossary/286/half-life | access-date=2020-02-20}}</ref><ref name="Curry 1993 pp. 127–144">{{서적 인용| last=Curry | first=Stephen H. | title=Antipsychotic Drugs and their Side-Effects | chapter=PHARMACOKINETICS OF ANTIPSYCHOTIC DRUGS | publisher=Elsevier | year=1993 | isbn=978-0-12-079035-7 | doi=10.1016/b978-0-12-079035-7.50015-4 | pages=127–144 | quote=The elimination half-life measures the kinetics of loss of drug from the body as a whole once all distribution equilibria have been achieved.}}</ref><ref name="Dasgupta Krasowski 2020 pp. 1–17">{{서적 인용| last1=Dasgupta | first1=Amitava | last2=Krasowski | first2=Matthew D. | title=Therapeutic Drug Monitoring Data | chapter=Pharmacokinetics and therapeutic drug monitoring | publisher=Elsevier | year=2020 | isbn=978-0-12-815849-4 | doi=10.1016/b978-0-12-815849-4.00001-3 | pages=1–17 | quote=The half-life of a drug is the time required for the serum concentration to be reduced by 50%. Once the half-life of the drug is known, the time required for clearance can be estimated. Approximately 97% of the drug is eliminated by 5 halflives, while ~99% is eliminated by 7 half-lives. }}</ref><ref>{{저널 인용| journal= Journal of Veterinary Pharmacology and Therapeutics| volume=27 | issue=6 | pages=427–439 | date=2004 | quote=Following i.v. administration, the terminal half-life is the time required for plasma/blood concentration to decrease by 50% after pseudo-equilibrium of distribution has been reached; then, terminal half-life is computed when the decrease in drug plasma concentration is due only to drug elimination, and the term ‘elimination half-life’ is applicable. Therefore, it is not the time necessary for the amount of the administered drug to fall by one half.| doi=10.1111/j.1365-2885.2004.00600.x | pmid=15601438 | title=Plasma terminal half-life | last1=Toutain | first1=P. L. | last2=Bousquet-Melou | first2=A. | archive-url=https://web.archive.org/web/20200220042629/http://physiologie.envt.fr/wp-content/uploads/2016/06/Plasma_terminal_half-life.pdf |url=http://physiologie.envt.fr/wp-content/uploads/2016/06/Plasma_terminal_half-life.pdf| archive-date=2020-02-20 }}</ref> 기호로는 <math>t_{\frac{1}{2}}</math>로 나타낸다.<ref name="AIDSinfo 2020"/><ref name="Dasgupta Krasowski 2020 pp. 1–17"/>