English: 5-year-old Mexican girl with Angelman syndrome, pedigree chart on left, photographs of her symptomatic features -- face and hands -- on right.

Fig1: Available family members. A) Pedigree of the proband and her family; B) Proband (III-1) with telecanthus, bilateral epicanthal folds, wide mouth, and an apparently happy demeanor; hands with tapered fingers, abnormal creases and broad thumbs.

A 5-year-old Mexican girl, first child of a healthy nonconsanguineous couple was evaluated. She was born at full term via caesarean section, which was indicated because of oligohydramnios detected in the last prenatal ultrasound; otherwise the pregnancy was uneventful. Her birth weight was 2800 g, length was 48 cm; Apgar score of 9.