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파일:Making of a DNA vaccine.jpg

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English: DNA vaccines are composed of a small, circular piece of DNA — called a DNA plasmid — that contains genes that code for proteins of a pathogen. When the vaccine is injected into the host, the inner machinery of the host cells “reads” the DNA and converts it into proteins from the pathogen. Recognizing that the proteins are foreign, the cells display them on their surface to alert the body’s immune system — both helper T cells, which spur the production of antibodies, and killer T cells, which kill infected cells outright.


ไทย: (คำแปลข้อความในรูป) วัคซีนไข้เวสต์ไนล์มียีน prM และ E ของไวรัส (สีเขียวและน้ำเงิน) ซึ่งเข้ารหัสโปรตีนเยื่อหุ้มไวรัส (transmembrane protein, M) และ glycosylated envelope protein (E) ตามลำดับ ชิ้น cDNA ที่มียีนทั้ง prM และ E จะนำไปใส่ดีเอ็นเอรูปกลมที่ไม่ใช่ของไวรัส WNV ซึ่งเรียกว่า พลาสมิด เมื่อวัคซีนเข้าไปในร่างกายแล้ว ก็จะสั่งการให้เซลล์ร่างกายผลิตโปรตีน prM และ E แล้วภูมิคุ้มกันก็จะตอบสนองต่อโปรตีนตามที่ว่าซึ่งเป็นการสร้างภูมิต้านโรคไข้เวสต์ไนล์
  1. ดึงอาร์เอ็นเอจากไวรัสเวสต์ไนล์ (WNV) ซึ่งทำลายตัวไวรัส แล้วอาร์เอ็นเอซึ่งเป็นรหัสพันธุกรรมแบบสายเดียวก็จะแปลงให้เป็นดีเอ็นเอซึ่งเป็นรหัสพันธุกรรมแบบสายคู่ ดีเอ็นเอที่ได้จะเป็นตัวแทนจีโนมของไวรัส
  2. ลำดับพันธุกรรมของ WNV จึงสามารถสร้างได้จากดีเอ็นเอที่ได้
  3. อาศัยลำดับพันธุกรรมจากดีเอ็นเอ ก็จะสร้างลำดับดีเอ็นเอสั้น ๆ ที่เรียกว่า ไพรเมอร์ (primer) ของบริเวณยีนคือ prM และ E ซึ่งก็เอาไปสร้างชิ้น complementary DNA (cDNA) ที่ประกอบด้วยยีนทั้ง prM และ E
  4. cDNA ที่ได้ก็จะนำไปใส่ดีเอ็นเอรูปกลมที่เรียกว่า พลาสมิด
  5. พลาสมิดซึ่งประกอบด้วยยีนทั้ง prM และ E จะเพาะขึ้นด้วยแบคทีเรียเป็นจำนวนมาก แล้วกลั่นให้บริสุทธิ์ด้วยวิธี column chromatography
  6. ผลิตภัณฑ์ที่ได้จะใช้เป็นวัคซีน
날짜 2005년경
date QS:P,+2005-00-00T00:00:00Z/9,P1480,Q5727902
출처 NIAID Begins Clinical Trial of West Nile Virus Vaccine on National Institute of Allergy and Infectious Diseases) site
저자 미상Unknown author
다른 버전
  • Ukrainian translation
    Ukrainian translation
  • translation to Spanish
    translation to Spanish


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현재2007년 12월 24일 (월) 22:022007년 12월 24일 (월) 22:02 판의 섬네일725 × 1,164 (210 KB)BiochemzaDNA vaccines are composed of a small, circular piece of DNA — called a DNA plasmid — that contains genes that code for proteins of a pathogen. When the vaccine is injected into the host, the inner machinery of the host cells “reads” the DNA an

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