IGF-1

소마토메딘 C(somatomedin C)라고도 불리는 인슐린유사 성장인자 1(Insulin like growth factor 1,IGF-1)은 어린 시절의 성장기 발달에 세포증식의 촉진과 관련해서 중요한 역할을 하는 인슐린과 분자 구조가 유사한 호르몬이며 성인에게는 신진 대사에 효과가 있다고 알려진 물질이다.

IGF1
사용 가능한 구조 PDB 동원체 검색: PDBe RCSB PDB ID 코드 목록 1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS
식별자
다른 이름	IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
외부 ID	OMIM: 147440 MGI: 96432 HomoloGene: 515 GeneCards: IGF1
유전자 위치 (인간) 염색체 12번 염색체 자리 12q23.2 시작 102,395,874 bp 끝 102,481,744 bp
유전자 위치 (쥐) 염색체 10번 염색체 (쥐) 자리 10 C1|10 43.7 cM 시작 87,694,127 bp 끝 87,772,904 bp
RNA 발현 패턴 Bgee 인간 쥐(동원체) 최상위 발현 심장막 tail of epididymis tendon of biceps brachii gastric mucosa superficial temporal artery 정낭 요도 caput epididymis 부고환몸통 자궁속막 최상위 발현 stria vascularis 속목동맥 efferent ductule 외경동맥 홍채 left lobe of liver 쓸개 stroma of bone marrow genital tubercle 백색지방조직 추가 참조 발현 데이터 BioGPS 추가 참조 발현 데이터
유전자 온톨로지 분자 함수 hormone activity insulin receptor binding growth factor activity integrin binding 단백질 결합 insulin-like growth factor receptor binding 세포 성분 세포밖공간 exocytic vesicle insulin-like growth factor binding protein complex platelet alpha granule lumen insulin-like growth factor ternary complex alphav-beta3 integrin-IGF-1-IGF1R complex 세포막 세포 바깥쪽 생물학적 과정 positive regulation of transcription regulatory region DNA binding skeletal system development positive regulation of glucose import muscle organ development positive regulation of Ras protein signal transduction response to heat positive regulation of cardiac muscle hypertrophy positive regulation of smooth muscle cell migration DNA 복제 positive regulation of insulin-like growth factor receptor signaling pathway phosphatidylinositol 3-kinase signaling positive regulation of DNA binding Ras protein signal transduction 세포 증식 positive regulation of mitotic nuclear division positive regulation of trophectodermal cell proliferation positive regulation of glycogen biosynthetic process positive regulation of fibroblast proliferation ERK1 and ERK2 cascade negative regulation of extrinsic apoptotic signaling pathway cell activation negative regulation of oocyte development positive regulation of transcription, DNA-templated bone mineralization involved in bone maturation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of MAPK cascade proteoglycan biosynthetic process positive regulation of activated T cell proliferation positive regulation of epithelial cell proliferation negative regulation of release of cytochrome c from mitochondria protein stabilization myotube cell development positive regulation of DNA replication myoblast proliferation skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration positive regulation of protein secretion positive regulation of glycoprotein biosynthetic process 유전자 발현의 조절 phosphatidylinositol-mediated signaling positive regulation of smooth muscle cell proliferation 근비대 protein kinase B signaling regulation of multicellular organism growth positive regulation of cell migration platelet degranulation positive regulation of calcineurin-NFAT signaling cascade positive regulation of phosphatidylinositol 3-kinase signaling myoblast differentiation glycolate metabolic process positive regulation of glycolytic process negative regulation of smooth muscle cell apoptotic process 신호전달 positive regulation of transcription by RNA polymerase II positive regulation of cell growth involved in cardiac muscle cell development positive regulation of cell population proliferation 조골세포 분화의 상향조절 activation of protein kinase B activity insulin-like growth factor receptor signaling pathway 세포자멸사 과정의 하향조절 positive regulation of tyrosine phosphorylation of STAT protein 신호전달 수용체 활성의 조절 positive regulation of gene expression negative regulation of gene expression cellular response to amyloid-beta positive regulation of vascular associated smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell apoptotic process negative regulation of interleukin-1 beta production negative regulation of tumor necrosis factor production negative regulation of neuroinflammatory response negative regulation of amyloid-beta formation 출처: Amigo / QuickGO
동원체 종 인간 쥐 앙트레 3479 16000 앙상블 ENSG00000017427 ENSMUSG00000020053 유니프롯 P05019 P05017 RefSeq (mRNA) NM_000618 NM_001111283 NM_001111284 NM_001111285 NM_001111274 NM_001111275 NM_001111276 NM_010512 NM_184052 NM_001314010 RefSeq(단백질) NP_000609 NP_001104753 NP_001104754 NP_001104755 NP_001104744 NP_001104745 NP_001104746 NP_001300939 NP_034642 위치(UCSC) Chr 12: 102.4 – 102.48 Mb Chr 10: 87.69 – 87.77 Mb PubMed 검색
위키데이터
인간 보기/편집 쥐 보기/편집

그러나 과학자들은 이러한 사실로 인해서 신체의 세포증식및 사멸의 사이클이 깨질수있는 불균형을 염려한다. 즉 세포증식의 효과가 신체가 불필요로하는 사멸주기에 들어간 대상 세포에까지 영향을 주어 안좋은 세포를 계속 증식시킴으로써 면역력에 악영향을 줄 수 있다는 견해를 언급하고있다.

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