SHB (유전자)

SHB
식별자
다른 이름	SHB, bA3J10.2, SH2 domain containing adaptor protein B
외부 ID	OMIM: 600314 MGI: 98294 HomoloGene: 74458 GeneCards: SHB
유전자 위치 (인간)
염색체	9번 염색체
끝	38,069,227 bp
유전자 위치 (쥐)
염색체	4번 염색체 (쥐)
끝	45,532,470 bp
RNA 발현 패턴
	최상위 발현
	귀밑샘; ; germinal epithelium; ; 양수; ; ganglionic eminence; ; 망막색소상피세포; ; 모낭; ; 벽가슴막; ; 눈꺼풀결막; ; 대정맥; ; 신장수질;
	최상위 발현
	ganglionic eminence; ; 식도; ; 대구치; ; 입술; ; secondary oocyte; ; medial ganglionic eminence; ; left lobe of liver; ; 콩팥; ; 심방; ; myocardium of ventricle;
	추가 참조 발현 데이터
	; ;
	추가 참조 발현 데이터
유전자 온톨로지
분자 함수	phosphotyrosine residue binding; 단백질 결합;
세포 성분	세포질; 세포막; 세포막; 핵질; 세포액; cytoplasmic ribonucleoprotein granule;
생물학적 과정	multicellular organism development; 세포 분화; vascular endothelial growth factor receptor signaling pathway; 혈관신생; 세포자살; positive regulation of signal transduction; 신호전달;
	출처: Amigo / QuickGO
동원체
	6461
	230126
	ENSG00000107338
	ENSMUSG00000044813
	Q15464
	Q6PD21
	NM_003028
	NM_001033306
	NP_003019
	NP_001028478
	위키데이터
인간 보기/편집	쥐 보기/편집

SH2 도메인 함유 어댑터 단백질 B(SH2 domain-containing adapter protein B)는 인간에서 SHB 유전자에 의해 암호화 된 단백질이다.^[5]^[6]

상호 작용 편집

SHB는 다음과 상호 작용하는 것으로 나타났다.

각주 편집

↑ ^가 ^나 ^다 GRCh38: Ensembl release 89: ENSG00000107338 - 앙상블, May 2017
↑ ^가 ^나 ^다 GRCm38: Ensembl release 89: ENSMUSG00000044813 - 앙상블, May 2017
↑ “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ “The SHB adaptor protein maps to human chromosome 9”. 《Genomics》 24 (3): 615–7. Dec 1994. doi:10.1006/geno.1994.1681. PMID 7713524.
↑ “Entrez Gene: SHB Src homology 2 domain containing adaptor protein B”.
↑ ^가 ^나 ^다 ^라 Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (Apr 1995). “Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins”. 《Oncogene》 10 (8): 1475–83. PMID 7537362.
↑ Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). “Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells”. 《The Journal of Biological Chemistry》 274 (39): 28050–7. doi:10.1074/jbc.274.39.28050. PMID 10488157.
↑ ^가 ^나 ^다 ^라 Lindholm CK, Henriksson ML, Hallberg B, Welsh M (Jul 2002). “Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells”. 《European Journal of Biochemistry / FEBS》 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.

추가 자료 편집

“Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins”. 《Oncogene》 10 (8): 1475–83. Apr 1995. PMID 7537362.
“Shb is a ubiquitously expressed Src homology 2 protein”. 《Oncogene》 9 (1): 19–27. Jan 1994. PMID 8302579.
“Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb”. 《Oncogene》 13 (5): 955–61. Sep 1996. PMID 8806685.
“Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins”. 《Oncogene》 16 (7): 891–901. Feb 1998. doi:10.1038/sj.onc.1201607. PMID 9484780.
“The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells”. 《Cell Growth & Differentiation》 9 (9): 757–66. Sep 1998. PMID 9751119.
“Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells”. 《The Journal of Biological Chemistry》 274 (39): 28050–7. Sep 1999. doi:10.1074/jbc.274.39.28050. PMID 10488157.
“Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis”. 《Blood》 95 (11): 3403–11. Jun 2000. PMID 10828022.
“Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization”. 《Experimental Cell Research》 257 (2): 245–54. Jun 2000. doi:10.1006/excr.2000.4896. PMID 10837138.
“NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway”. 《Experimental Cell Research》 259 (2): 370–7. Sep 2000. doi:10.1006/excr.2000.4984. PMID 10964504.
“SH2-Bbeta is a Rac-binding protein that regulates cell motility”. 《The Journal of Biological Chemistry》 277 (12): 10669–77. Mar 2002. doi:10.1074/jbc.M111138200. PMID 11786545.
“Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells”. 《European Journal of Biochemistry / FEBS》 269 (13): 3279–88. Jul 2002. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.
“The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells”. 《Molecular Biology of the Cell》 13 (8): 2881–93. Aug 2002. doi:10.1091/mbc.E02-02-0103. PMC 117949. PMID 12181353.
“IL-2 receptor signaling through the Shb adapter protein in T and NK cells”. 《Biochemical and Biophysical Research Communications》 296 (4): 929–36. Aug 2002. doi:10.1016/S0006-291X(02)02016-8. PMID 12200137.
“The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells”. 《Cellular Signalling》 15 (2): 171–9. Feb 2003. doi:10.1016/S0898-6568(02)00076-1. PMID 12464388.
“Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins”. 《Molecular Medicine》 8 (11): 695–704. Nov 2002. doi:10.1007/BF03402033. PMC 2039954. PMID 12520086.
“The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration”. 《The Journal of Biological Chemistry》 279 (21): 22267–75. May 2004. doi:10.1074/jbc.M312729200. PMID 15026417.

[refGRCh38Ensembl-1] 가 ^나 ^다 GRCh38: Ensembl release 89: ENSG00000107338 - 앙상블, May 2017

[refGRCm38Ensembl-2] 가 ^나 ^다 GRCm38: Ensembl release 89: ENSMUSG00000044813 - 앙상블, May 2017

[3] “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[4] “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[pmid7713524-5] “The SHB adaptor protein maps to human chromosome 9”. 《Genomics》 24 (3): 615–7. Dec 1994. doi:10.1006/geno.1994.1681. PMID 7713524.

[entrez-6] “Entrez Gene: SHB Src homology 2 domain containing adaptor protein B”.

[pmid7537362-7] 가 ^나 ^다 ^라 Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (Apr 1995). “Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins”. 《Oncogene》 10 (8): 1475–83. PMID 7537362.

[pmid10488157-8] Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). “Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells”. 《The Journal of Biological Chemistry》 274 (39): 28050–7. doi:10.1074/jbc.274.39.28050. PMID 10488157.

[pmid12084069-9] 가 ^나 ^다 ^라 Lindholm CK, Henriksson ML, Hallberg B, Welsh M (Jul 2002). “Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells”. 《European Journal of Biochemistry / FEBS》 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.

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