SPARCL1

SPARCL1
식별자
다른 이름	SPARCL1, MAST 9, MAST9, PIG33, SC1, SPARC like 1
외부 ID	OMIM: 606041 MGI: 108110 HomoloGene: 3438 GeneCards: SPARCL1
유전자 위치 (인간)
염색체	4번 염색체
끝	87,531,061 bp
유전자 위치 (쥐)
염색체	5번 염색체 (쥐)
끝	104,261,599 bp
RNA 발현 패턴
	최상위 발현
	middle temporal gyrus; ; 중심뒤이랑; ; superior frontal gyrus; ; Brodmann area 23; ; 안와전두피질; ; external globus pallidus; ; Region I of hippocampus proper; ; 후두엽; ; Brodmann area 46; ; entorhinal cortex;
	최상위 발현
	dorsal tegmental nucleus; ; medial vestibular nucleus; ; cerebellar vermis; ; 배쪽 피개부; ; 담창구; ; pontine nuclei; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; 유두체; ; 외측슬상핵;
	추가 참조 발현 데이터
	추가 참조 발현 데이터
유전자 온톨로지
분자 함수	금속 이온 결합; calcium ion binding; collagen binding; extracellular matrix binding; 단백질 결합;
세포 성분	엑소좀; 세포 바깥쪽; endoplasmic reticulum lumen; 세포밖공간; collagen-containing extracellular matrix; glutamatergic synapse;
생물학적 과정	신호전달; anatomical structure development; 번역 후 변형; synaptic membrane adhesion;
	출처: Amigo / QuickGO
동원체
	8404
	13602
	ENSG00000152583
	ENSMUSG00000029309
	Q14515
	P70663
	NM_004684; NM_001128310; NM_001291976; NM_001291977
	NM_010097; NM_001359014; NM_001359016
	NP_001121782; NP_001278905; NP_001278906; NP_004675
	NP_034227; NP_001345943; NP_001345945
	위키데이터
인간 보기/편집	쥐 보기/편집

SPARC 유사 단백질 1(SPARC-like protein 1, SPARCL1 또는 SC1) 또는 헤빈(Hevin, High Endothelial Venule Protein)은 SPARC와 구조적 유사성이 높은 분비 단백질이다.^[5]^[6] 이것은 세포 연접의 중간 상태를 생성하기 위해 세포외기질과 상호작용한다.^[7] 암 전이 및 염증과 관련된 동적 세포 외 역할로 인해 모세포 단백질로 간주된다.^[8]^[9] 인간에서 헤빈은 SPARCL1 유전자에 의해 암호화된다.^[10]^[11]

상호작용 편집

CALY^[12]

참고 편집

트롬보스폰딘
테나신

각주 편집

↑ ^가 ^나 ^다 GRCh38: Ensembl release 89: ENSG00000152583 - 앙상블, May 2017
↑ ^가 ^나 ^다 GRCm38: Ensembl release 89: ENSMUSG00000029309 - 앙상블, May 2017
↑ “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ “Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC”. 《Immunity》 2 (1): 113–23. January 1995. doi:10.1016/1074-7613(95)90083-7. PMID 7600298.
↑ “SC1/hevin. An extracellular calcium-modulated protein that binds collagen I”. 《The Journal of Biological Chemistry》 278 (13): 11351–8. March 2003. doi:10.1074/jbc.M212291200. PMID 12538579.
↑ “Matricellular hevin regulates decorin production and collagen assembly”. 《The Journal of Biological Chemistry》 281 (37): 27621–32. September 2006. doi:10.1074/jbc.M510507200. PMID 16844696.
↑ “Matricellular proteins and biomaterials”. 《Matrix Biology》 37: 183–91. July 2014. doi:10.1016/j.matbio.2014.03.002. PMC 4167162. PMID 24657843.
↑ “Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family”. 《The International Journal of Biochemistry & Cell Biology》 36 (6): 991–6. June 2004. doi:10.1016/j.biocel.2004.01.017. PMID 15094114.
↑ “cDNA subtraction library construction using a magnet-assisted subtraction technique (MAST)”. 《Trends in Genetics》 9 (3): 70–1. March 1993. doi:10.1016/0168-9525(93)90216-5. PMID 8488563.
↑ “Entrez Gene: SPARCL1 SPARC-like 1 (mast9, hevin)”.
↑ “Hevin-calcyon interaction promotes synaptic reorganization after brain injury”. 《Cell Death and Differentiation》. March 2021. doi:10.1038/s41418-021-00772-5. ISSN 1350-9047. PMID 33753902.

[refGRCh38Ensembl-1] 가 ^나 ^다 GRCh38: Ensembl release 89: ENSG00000152583 - 앙상블, May 2017

[refGRCm38Ensembl-2] 가 ^나 ^다 GRCm38: Ensembl release 89: ENSMUSG00000029309 - 앙상블, May 2017

[3] “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[4] “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[pmid7600298-5] “Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC”. 《Immunity》 2 (1): 113–23. January 1995. doi:10.1016/1074-7613(95)90083-7. PMID 7600298.

[6] “SC1/hevin. An extracellular calcium-modulated protein that binds collagen I”. 《The Journal of Biological Chemistry》 278 (13): 11351–8. March 2003. doi:10.1074/jbc.M212291200. PMID 12538579.

[pmid16844696-7] “Matricellular hevin regulates decorin production and collagen assembly”. 《The Journal of Biological Chemistry》 281 (37): 27621–32. September 2006. doi:10.1074/jbc.M510507200. PMID 16844696.

[8] “Matricellular proteins and biomaterials”. 《Matrix Biology》 37: 183–91. July 2014. doi:10.1016/j.matbio.2014.03.002. PMC 4167162. PMID 24657843.

[9] “Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family”. 《The International Journal of Biochemistry & Cell Biology》 36 (6): 991–6. June 2004. doi:10.1016/j.biocel.2004.01.017. PMID 15094114.

[pmid8488563-10] “cDNA subtraction library construction using a magnet-assisted subtraction technique (MAST)”. 《Trends in Genetics》 9 (3): 70–1. March 1993. doi:10.1016/0168-9525(93)90216-5. PMID 8488563.

[entrez-11] “Entrez Gene: SPARCL1 SPARC-like 1 (mast9, hevin)”.

[KimJung2021-12] “Hevin-calcyon interaction promotes synaptic reorganization after brain injury”. 《Cell Death and Differentiation》. March 2021. doi:10.1038/s41418-021-00772-5. ISSN 1350-9047. PMID 33753902.

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