TNFAIP3

종양 괴사 인자, 알파 유도 단백질 3 또는 A20은 인간에서 TNFAIP3 유전자에 의해 인코딩되는 단백질이다.

TNFAIP3
사용 가능한 구조 PDB 동원체 검색: PDBe RCSB PDB ID 코드 목록 2EQF, 2EQG, 2VFJ, 3DKB, 3OJ3, 3OJ4, 3VUW, 3VUX, 3VUY, 3ZJD, 3ZJE, 3ZJF, 3ZJG, 4ZRH, 4ZS5
식별자
다른 이름	TNFAIP3, A20, OTUD7C, TNFA1P2, AISBL, TNF alpha induced protein 3, AIFBL1
외부 ID	OMIM: 191163 MGI: 1196377 HomoloGene: 4582 GeneCards: TNFAIP3
유전자 위치 (인간) 염색체 6번 염색체 자리 6q23.3 시작 137,867,214 bp 끝 137,883,312 bp
유전자 위치 (쥐) 염색체 10번 염색체 (쥐) 자리 10 A3|10 8.08 cM 시작 18,876,658 bp 끝 18,891,405 bp
RNA 발현 패턴 Bgee 인간 쥐(동원체) 최상위 발현 대정맥 mucosa of paranasal sinus 충수 epithelium of nasopharynx 심장막 mucosa of urinary bladder skin of thigh 가슴샘 림프절 cartilage tissue 최상위 발현 neural layer of retina 망막색소상피세포 mesenteric lymph nodes 가슴샘 epithelium of lens 과립구 Paneth cell 공장 left colon stroma of bone marrow 추가 참조 발현 데이터 BioGPS 추가 참조 발현 데이터
유전자 온톨로지 분자 함수 DNA 결합 cysteine-type peptidase activity zinc ion binding 금속 이온 결합 ubiquitin-protein transferase activity protease binding protein self-association 펩티데이스 활성 ligase activity kinase binding K63-linked polyubiquitin modification-dependent protein binding ubiquitin binding 단백질 결합 catalytic activity thiol-dependent deubiquitinase 가수분해효소 활성 identical protein binding Lys63-specific deubiquitinase activity transferase activity 세포 성분 세포질 세포액 리소좀 엑소좀 세포핵 intracellular membrane-bounded organelle 생물학적 과정 regulation of germinal center formation positive regulation of hepatocyte proliferation negative regulation of endothelial cell apoptotic process negative regulation of interleukin-1 beta production negative regulation of smooth muscle cell proliferation regulation of vascular wound healing B-1 B cell homeostasis protein K48-linked deubiquitination positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity regulation of defense response to virus by host protein deubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of toll-like receptor 2 signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway regulation of tumor necrosis factor-mediated signaling pathway negative regulation of interleukin-6 production negative regulation of B cell activation negative regulation of toll-like receptor 5 signaling pathway tolerance induction to lipopolysaccharide response to muramyl dipeptide negative regulation of chronic inflammatory response negative regulation of cell death negative regulation of I-kappaB kinase/NF-kappaB signaling 단백질분해과정 establishment of protein localization to vacuole protein deubiquitination negative regulation of protein ubiquitination protein K48-linked ubiquitination protein K63-linked deubiquitination negative regulation of CD40 signaling pathway negative regulation of extrinsic apoptotic signaling pathway via death domain receptors protein complex oligomerization protein K11-linked deubiquitination regulation of inflammatory response negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway negative regulation of innate immune response negative regulation of osteoclast proliferation negative regulation of tumor necrosis factor production negative regulation of type I interferon production 물질대사 inflammatory response response to molecule of bacterial origin negative regulation of NF-kappaB transcription factor activity negative regulation of interleukin-2 production negative regulation of inflammatory response negative regulation of toll-like receptor 3 signaling pathway nucleotide-binding oligomerization domain containing signaling pathway cellular response to lipopolysaccharide negative regulation of toll-like receptor 4 signaling pathway negative regulation of bone resorption cellular response to hydrogen peroxide 세포자살 protein ubiquitination cytoskeleton organization cell migration positive regulation of Wnt signaling pathway protein K29-linked deubiquitination protein K33-linked deubiquitination 출처: Amigo / QuickGO
동원체 종 인간 쥐 앙트레 7128 21929 앙상블 ENSG00000118503 ENSMUSG00000019850 유니프롯 P21580 Q60769 RefSeq (mRNA) NM_001270507 NM_001270508 NM_006290 NM_001166402 NM_009397 RefSeq(단백질) NP_001257436 NP_001257437 NP_006281 NP_001159874 NP_033423 위치(UCSC) Chr 6: 137.87 – 137.88 Mb Chr 10: 18.88 – 18.89 Mb PubMed 검색
위키데이터
인간 보기/편집 쥐 보기/편집

해당 유전자는 종양괴사인자(TNF)에 의해 발현이 빠르게 유도되는 유전자로 확인됐다. 이 유전자에 의해 암호화된 단백질은 징크핑거 단백질과 유비퀴틴화 효소이며, NF-카파 B 활성화와 TNF 매개 세포사멸을 억제하는 것으로 나타났다. A20 단백질은 고대의 것이며 단백질 상동체는 보존된 단백질 도메인 구성을 가진 자포(산호, 해파리, 아네모네)까지 거슬러 올라간다. TNFAIP3 및 이의 전사 억제인자(즉, KCHIP3)의 녹아웃 마우스 모델을 사용하여 TNFAIP3은 내독소 및 TNF 유발 NF-카파 B 반응을 종료하여 염증을 제한하는 데 중요한 것으로 나타났다. 간단히 말해서, TNFAIP3의 데유비퀴티나제 기능은 내피 부착 접합부에서 VE-카드헤린의 손실을 방지하기 위해 VE-카드헤린에서 유비퀴틴 사슬을 제거하는 것으로 나타났다.

외부 링크

• 모든 구조 정보의 개요는 유니프롯의 PDB로 볼 수 있습니다: P21580 (Tumor necrosis factor alpha-induced protein 3) - PDBe-KB.