소닉 헤지호그

비디오 게임 캐릭터에 대해서는 소닉 더 헤지혹 (캐릭터) 문서를 참고하십시오.

소닉 헤지호그(sonic hedgehog)는 SHH 유전자를 위해 인코딩된 단백질이다. 이 단백질의 이름은 소닉 더 헤지혹이라는 캐릭터의 이름을 따라 지어졌다.

SHH
사용 가능한 구조 PDB 동원체 검색: PDBe RCSB PDB ID 코드 목록 3HO5, 3M1N, 3MXW
식별자
다른 이름	SHH, HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS, sonic hedgehog, Sonic hedgehog, ShhNC, sonic hedgehog signaling molecule
외부 ID	OMIM: 600725 MGI: 98297 HomoloGene: 30961 GeneCards: SHH
유전자 위치 (인간) 염색체 7번 염색체 자리 7q36.3 시작 155,799,980 bp 끝 155,812,463 bp
유전자 위치 (쥐) 염색체 5번 염색체 (쥐) 자리 5 B1|5 14.39 cM 시작 28,661,813 bp 끝 28,672,254 bp
RNA 발현 패턴 Bgee 인간 쥐(동원체) 최상위 발현 간오른엽 pancreatic epithelial cell 장딴지신경 쓸개 방광 배근 신경절 콩팥 body of stomach upper lobe of left lung 오른허파 최상위 발현 대구치 앞니 혀 뒤창자 left lung lobe 척삭 epithelium of stomach enamel knot incisive bone 모낭 추가 참조 발현 데이터 BioGPS 추가 참조 발현 데이터
유전자 온톨로지 분자 함수 calcium ion binding 금속 이온 결합 patched binding 펩티데이스 활성 zinc ion binding laminin-1 binding glycosaminoglycan binding morphogen activity 가수분해효소 활성 단백질 결합 endopeptidase activity 세포 성분 세포액 endoplasmic reticulum lumen 세포막 세포 표면 지질뗏목 세포막 세포 바깥쪽 세포밖공간 세포외기질 생물학적 과정 positive regulation of skeletal muscle cell proliferation pattern specification process myotube differentiation mesenchymal cell proliferation male genitalia development bud outgrowth involved in lung branching limb bud formation T cell differentiation in thymus embryonic pattern specification positive regulation of skeletal muscle tissue development positive regulation of immature T cell proliferation in thymus positive regulation of kidney smooth muscle cell differentiation negative regulation of Wnt signaling pathway anatomical structure formation involved in morphogenesis ectoderm development hindgut morphogenesis spinal cord dorsal/ventral patterning formation of anatomical boundary oligodendrocyte differentiation trachea development prostate gland development negative regulation of transcription elongation from RNA polymerase II promoter limb development vasculogenesis primary prostatic bud elongation heart looping telencephalon regionalization odontogenesis of dentin-containing tooth positive regulation of mesenchymal cell proliferation 혈관신생 positive regulation of epithelial cell proliferation involved in prostate gland development positive regulation of striated muscle cell differentiation negative regulation of proteasomal ubiquitin-dependent protein catabolic process embryonic digestive tract morphogenesis apoptotic signaling pathway inner ear development hair follicle morphogenesis 세포 증식 metanephros development lung epithelium development negative regulation of canonical Wnt signaling pathway regulation of proteolysis branching involved in salivary gland morphogenesis negative regulation of mesenchymal cell apoptotic process positive regulation of neuroblast proliferation dopaminergic neuron differentiation intermediate filament organization renal system development cell fate commitment DNA를 주형으로 한 전사의 조절 positive regulation of smoothened signaling pathway androgen metabolic process kidney development lung development negative regulation of protein catabolic process thymus development embryonic organ development negative regulation of cell differentiation negative regulation of dopaminergic neuron differentiation embryonic digit morphogenesis negative regulation of alpha-beta T cell differentiation positive regulation of sclerotome development epithelial-mesenchymal cell signaling negative regulation of gene expression lymphoid progenitor cell differentiation negative thymic T cell selection positive regulation of transcription, DNA-templated positive regulation of Wnt signaling pathway ventral midline development central nervous system development heart development branching involved in ureteric bud morphogenesis negative regulation of T cell proliferation embryonic limb morphogenesis positive regulation of cell differentiation branching involved in prostate gland morphogenesis positive regulation of mesenchymal cell proliferation involved in ureter development establishment of cell polarity branching involved in blood vessel morphogenesis positive regulation of cerebellar granule cell precursor proliferation neuroblast proliferation pancreas development positive regulation of protein import into nucleus smoothened signaling pathway oligodendrocyte development camera-type eye development spinal cord motor neuron differentiation positive regulation of alpha-beta T cell differentiation digestive tract morphogenesis hair follicle development positive regulation of oligodendrocyte differentiation roof of mouth development left lung development striated muscle tissue development positive regulation of T cell differentiation in thymus cellular response to lithium ion embryonic foregut morphogenesis anatomical structure development thalamus development stem cell development smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation cell fate specification 세포자멸사 과정의 하향조절 negative regulation of transcription by RNA polymerase II regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry 단백질분해과정 embryonic skeletal system development regulation of protein localization to nucleus odontogenesis respiratory tube development regulation of prostatic bud formation thyroid gland development negative regulation of cell migration developmental growth right lung development determination of left/right asymmetry in lateral mesoderm positive thymic T cell selection mesenchymal smoothened signaling pathway involved in prostate gland development canonical Wnt signaling pathway 유전자 발현의 조절 osteoblast development negative regulation of cholesterol efflux dorsal/ventral neural tube patterning regulation of epithelial cell proliferation involved in prostate gland development epithelial-mesenchymal signaling involved in prostate gland development dorsal/ventral pattern formation branching morphogenesis of an epithelial tube lung lobe morphogenesis embryonic forelimb morphogenesis midbrain development skin development regulation of odontogenesis regulation of mesenchymal cell proliferation involved in prostate gland development mesenchymal cell proliferation involved in lung development positive regulation of hh target transcription factor activity prostate epithelial cord elongation metanephric mesenchymal cell proliferation involved in metanephros development 세포내이입 lung morphogenesis cell development trachea morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis cell-cell signaling salivary gland cavitation hindbrain development 혈액응고 negative regulation of kidney smooth muscle cell differentiation somite development cerebellar granule cell precursor proliferation axon guidance negative regulation of ureter smooth muscle cell differentiation positive regulation of ureter smooth muscle cell differentiation multicellular organism development animal organ formation intein-mediated protein splicing determination of left/right symmetry vasculature development positive regulation of gene expression regulation of cell population proliferation embryonic morphogenesis neural crest cell migration polarity specification of anterior/posterior axis positive regulation of cell population proliferation artery development protein localization to nucleus Bergmann glial cell differentiation forebrain development neuron fate commitment CD4-positive or CD8-positive, alpha-beta T cell lineage commitment striated muscle cell differentiation myoblast differentiation lung-associated mesenchyme development epithelial tube branching involved in lung morphogenesis positive regulation of cell division positive regulation of transcription by RNA polymerase II anterior/posterior pattern specification embryonic hindlimb morphogenesis forebrain regionalization cell proliferation in external granule layer tracheoesophageal septum formation 신호전달 수용체 활성의 조절 출처: Amigo / QuickGO
동원체 종 인간 쥐 앙트레 6469 20423 앙상블 ENSG00000164690 ENSMUSG00000002633 유니프롯 Q15465 Q62226 RefSeq (mRNA) NM_000193 NM_001310462 NM_009170 RefSeq(단백질) NP_000184 NP_001297391 NP_033196 위치(UCSC) Chr 7: 155.8 – 155.81 Mb Chr 5: 28.66 – 28.67 Mb PubMed 검색
위키데이터
인간 보기/편집 쥐 보기/편집

이 신호 분자는 각기 다른 모든 유형의 동물의 배아형태발생을 규제하는 핵심 요소이다.

외부 링크

• 모든 구조 정보의 개요는 유니포트의 PDB로 볼 수 있습니다: Q15465 (Human Sonic hedgehog protein) - PDBe-KB.
• 모든 구조 정보의 개요는 유니포트의 PDB로 볼 수 있습니다: Q62226 (Mouse Sonic hedgehog protein) - PDBe-KB.