BHLHB2

클래스 E 기본 나선-루프-나선 단백질 40(BHLHB2)은 인간에서 BHLHE40 유전자에 의해 암호화 된 단백질이다.

BHLHE40
식별자
다른 이름	BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14, basic helix-loop-helix family member e40, Clast5, SHARP2
외부 ID	OMIM: 604256 MGI: 1097714 HomoloGene: 2722 GeneCards: BHLHE40
유전자 위치 (인간) 염색체 3번 염색체 자리 3p26.1 시작 4,979,437 bp 끝 4,985,323 bp
유전자 위치 (쥐) 염색체 6번 염색체 (쥐) 자리 6|6 E2 시작 108,637,590 bp 끝 108,643,886 bp
RNA 발현 패턴 Bgee 인간 쥐(동원체) 최상위 발현 saphenous vein 대정맥 synovial joint 심장막 gastric mucosa 음경 쓸개 유관 기관 mucosa of urinary bladder 최상위 발현 발목 장딴지빗근 긴발가락폄근 자궁경부 홍채 left lobe of liver 앞정강근 모양체 위팔세갈래근 넙다리네갈래근 추가 참조 발현 데이터 BioGPS 추가 참조 발현 데이터
유전자 온톨로지 분자 함수 DNA 결합 protein dimerization activity protein homodimerization activity MRF binding transcription corepressor activity protein domain specific binding DNA-binding transcription factor activity DNA-binding transcription repressor activity, RNA polymerase II-specific bHLH transcription factor binding E-box binding 단백질 결합 protein heterodimerization activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription factor binding sequence-specific DNA binding sequence-specific double-stranded DNA binding 세포 성분 세포질 세포핵 nuclear body 생물학적 과정 DNA를 주형으로 한 전사의 조절 response to light stimulus rhythmic process negative regulation of transcription by RNA polymerase II circadian regulation of gene expression DNA를 주형으로 한 전사 negative regulation of DNA-binding transcription factor activity negative regulation of transcription, DNA-templated entrainment of circadian clock by photoperiod 일주기 생체 리듬 somitogenesis Notch signaling pathway 세포 분화 regulation of neurogenesis 출처: Amigo / QuickGO
동원체 종 인간 쥐 앙트레 8553 20893 앙상블 ENSG00000134107 ENSMUSG00000030103 유니프롯 O14503 O35185 RefSeq (mRNA) NM_003670 NM_011498 RefSeq(단백질) NP_003661 NP_035628 위치(UCSC) Chr 3: 4.98 – 4.99 Mb Chr 6: 108.64 – 108.64 Mb PubMed 검색
위키데이터
인간 보기/편집 쥐 보기/편집

기능

DEC1은 다양한 조직에서 발현된 기본 나선-루프-나선 단백질을 암호화한다. 연골 세포에서의 발현은 Bt2cAMP의 첨가에 반응한다. 분화된 배아 연골 세포 발현 유전자 1은 세포 분화의 조절에 관여하는 것으로 여겨진다.

추가 자료

• “Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2”. 《Journal of Biochemistry》 129 (3): 391–6. Mar 2001. doi:10.1093/oxfordjournals.jbchem.a002869. PMID 11226878. 
• “Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway”. 《The Journal of Biological Chemistry》 276 (18): 15306–15. May 2001. doi:10.1074/jbc.M010516200. PMID 11278694. 
• “Defective T cell activation and autoimmune disorder in Stra13-deficient mice”. 《Nature Immunology》 2 (11): 1040–7. Nov 2001. doi:10.1038/ni721. PMID 11668339. 
• “Identification of genes differentially induced by hypoxia in pancreatic cancer cells”. 《Biochemical and Biophysical Research Communications》 288 (4): 882–6. Nov 2001. doi:10.1006/bbrc.2001.5867. PMID 11688991. 
• “Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation”. 《The Biochemical Journal》 367 (Pt 2): 413–22. Oct 2002. doi:10.1042/BJ20020514. PMC 1222902. PMID 12119049. 
• “Stra13 homodimers repress transcription through class B E-box elements”. 《The Journal of Biological Chemistry》 277 (48): 46544–51. Nov 2002. doi:10.1074/jbc.M111652200. PMID 12297495. 
• “Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes”. 《The Journal of Biological Chemistry》 277 (49): 47014–21. Dec 2002. doi:10.1074/jbc.M204938200. PMID 12354771. 
• “Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages”. 《The Journal of Biological Chemistry》 277 (51): 50112–20. Dec 2002. doi:10.1074/jbc.M206771200. PMID 12384505. 
• “Dec1 and Dec2 are regulators of the mammalian molecular clock”. 《Nature》 419 (6909): 841–4. Oct 2002. doi:10.1038/nature01123. PMID 12397359. 
• “DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter”. 《The Journal of Biological Chemistry》 278 (19): 16899–907. May 2003. doi:10.1074/jbc.M300596200. PMID 12624110. 
• “DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer”. 《The Journal of Pathology》 200 (2): 222–8. Jun 2003. doi:10.1002/path.1330. PMID 12754744. 
• “STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets”. 《Journal of Molecular Biology》 340 (4): 641–53. Jul 2004. doi:10.1016/j.jmb.2004.05.025. PMID 15223310. 
• “Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1”. 《European Journal of Biochemistry / FEBS》 271 (22): 4409–19. Nov 2004. doi:10.1111/j.1432-1033.2004.04379.x. PMID 15560782. 
• “Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins”. 《Cellular and Molecular Life Sciences》 62 (4): 471–84. Feb 2005. doi:10.1007/s00018-004-4423-2. PMID 15719173. 
• “STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker”. 《Journal of Medical Genetics》 42 (7): 565–76. Jul 2005. doi:10.1136/jmg.2004.029835. PMC 1736099. PMID 15994878. 
• “A human protein-protein interaction network: a resource for annotating the proteome”. 《Cell》 122 (6): 957–68. Sep 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.