TLE2

TLE2
식별자
다른 이름	TLE2, ESG, ESG2, GRG2, transducin like enhancer of split 2, TLE family member 2, transcriptional corepressor
외부 ID	OMIM: 601041 MGI: 104635 HomoloGene: 20693 GeneCards: TLE2
유전자 위치 (인간)
염색체	19번 염색체
끝	3,047,635 bp
유전자 위치 (쥐)
염색체	10번 염색체 (쥐)
끝	81,426,679 bp
RNA 발현 패턴
	최상위 발현
	cerebellar hemisphere; ; cerebellar vermis; ; 정강신경; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; 왼자궁관; ; 귀밑샘; ; 장딴지신경; ; 작은침샘; ; 자궁목관;
	최상위 발현
	cerebellar cortex; ; medullary collecting duct; ; cerebellar vermis; ; 속목동맥; ; 부신; ; superior frontal gyrus; ; 대구치; ; 외경동맥; ; 구형낭; ; 난소;
	추가 참조 발현 데이터
	; ;
	추가 참조 발현 데이터
유전자 온톨로지
분자 함수	단백질 결합; transcription corepressor activity;
세포 성분	세포핵; focal adhesion; 핵질; 세포 바깥쪽; nuclear body; transcription regulator complex;
생물학적 과정	animal organ morphogenesis; negative regulation of transcription, DNA-templated; DNA를 주형으로 한 전사의 조절; 윈트 신호전달; negative regulation of canonical Wnt signaling pathway; DNA를 주형으로 한 전사; 신호전달; beta-catenin-TCF complex assembly;
	출처: Amigo / QuickGO
동원체
	7089
	21886
	ENSG00000065717
	ENSMUSG00000034771
	Q04725
	Q9WVB2
	NM_001144761; NM_001144762; NM_001300846; NM_003260
	NM_001252401; NM_019725
	NP_001138233; NP_001138234; NP_001287775; NP_003251
	NP_001239330; NP_062699
	위키데이터
인간 보기/편집	쥐 보기/편집

트랜스듀신 유사 증폭자 단백질 2(Transducin-like enhancer protein 2 )는 인간에서 TLE2 유전자에 의해 암호화되는 단백질이다.^[5]^[6]

상호 작용 편집

TLE2는 TLE1^[7] 및 HES1과 상호 작용하는 것으로 나타났다.

각주 편집

↑ ^가 ^나 ^다 GRCh38: Ensembl release 89: ENSG00000065717 - 앙상블, May 2017
↑ ^가 ^나 ^다 GRCm38: Ensembl release 89: ENSMUSG00000034771 - 앙상블, May 2017
↑ “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ “Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia”. 《Genomics》 31 (1): 58–64. Oct 1996. doi:10.1006/geno.1996.0009. PMID 8808280.
↑ “Entrez Gene: TLE2 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)”.
↑ Grbavec, D; Lo R; Liu Y; Stifani S (Dec 1998). “Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development”. 《Eur. J. Biochem.》 (GERMANY) 258 (2): 339–49. doi:10.1046/j.1432-1327.1998.2580339.x. ISSN 0014-2956. PMID 9874198.

[refGRCh38Ensembl-1] 가 ^나 ^다 GRCh38: Ensembl release 89: ENSG00000065717 - 앙상블, May 2017

[refGRCm38Ensembl-2] 가 ^나 ^다 GRCm38: Ensembl release 89: ENSMUSG00000034771 - 앙상블, May 2017

[3] “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[4] “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[pmid8808280-5] “Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia”. 《Genomics》 31 (1): 58–64. Oct 1996. doi:10.1006/geno.1996.0009. PMID 8808280.

[entrez-6] “Entrez Gene: TLE2 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)”.

[pmid9874198-7] Grbavec, D; Lo R; Liu Y; Stifani S (Dec 1998). “Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development”. 《Eur. J. Biochem.》 (GERMANY) 258 (2): 339–49. doi:10.1046/j.1432-1327.1998.2580339.x. ISSN 0014-2956. PMID 9874198.

[5]

[6]

[1]

[2]

[3]

[4]

[7]