위키백과

알프레드 G. 길먼

미국의 생화학자

알프레드 굿맨 길먼(영어: Alfred Goodman Gilman, 1941년 7월 1일 ~ 2015년 12월 23일)은 미국의 생화학자, 약리학자[1]이다. 1994년에 세포막에 존재하는 G단백질을 발견한 공로로 마틴 로드벨과 함께 노벨 생리학·의학상을 수상했다.[2]

알프레드 G. 길먼
Alfred G. Gilman
1994년 촬영
1994년 촬영
출생 1941년 7월 1일(1941-07-01)
미국 코네티컷주 뉴헤이븐
사망 2015년 12월 23일(2015-12-23) (향년 74세)
미국 텍사스주 댈러스
국적 미국
주요 업적 G단백질
수상 John J. Abel Award(1975년)
리처드 런즈베리상(1987년)
루이자 그로스 호르위츠상(1989년)
노벨 생리학·의학상(1994년)
분야 생화학, 약리학

수상 경력 편집

주요 논문 편집

  • Seeds, NW; Gilman, AG (1971). “Norepinephrine stinulated increase of cyclic AMP levels in developing mouse brain cell cultures”. 《Science》 174 (4006): 292. doi:10.1126/science.174.4006.292. PMID 4330303. 
  • Gilman, AG; Nirenberg, M (1971). “Regulation of adenosine 3',5'-cyclic monophosphate metabolism in cultured neuroblastoma cells”. 《Nature》 234 (5328): 356–8. doi:10.1038/234356a0. PMID 4332686. 
  • Secrist JA, 3rd; Barrio, JR; Leonard, NJ; Villar-Palasi, C; Gilman, AG (1972). “Fluorescent modification of adenosine 3',5'-monophosphate: spectroscopic properties and activity in enzyme systems”. 《Science》 177 (4045): 279–80. doi:10.1126/science.177.4045.279. PMID 4339302. 
  • Sternweis, PC; Northup, JK; Smigel, MD; Gilman, AG (1981). “The regulatory component of adenylate cyclase. Purification and properties”. 《The Journal of Biological Chemistry》 256 (22): 11517–26. PMID 6271754. 
  • Hanski, E; Sternweis, PC; Northup, JK; Dromerick, AW; Gilman, AG (1981). “The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein”. 《The Journal of Biological Chemistry》 256 (24): 12911–9. PMID 6273414. 
  • Schleifer, LS; Kahn, RA; Hanski, E; Northup, JK; Sternweis, PC; Gilman, AG (1982). “Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase”. 《The Journal of Biological Chemistry》 257 (1): 20–3. PMID 6273425. 
  • Northup, JK; Smigel, MD; Gilman, AG (1982). “The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding”. 《The Journal of Biological Chemistry》 257 (19): 11416–23. PMID 6288684. 
  • Manning, DR; Gilman, AG (1983). “The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins”. 《The Journal of Biological Chemistry》 258 (11): 7059–63. PMID 6304074. 
  • Northup, JK; Sternweis, PC; Gilman, AG (1983). “The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit”. 《The Journal of Biological Chemistry》 258 (18): 11361–8. PMID 6309843. 
  • Northup, JK; Smigel, MD; Sternweis, PC; Gilman, AG (1983). “The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit”. 《The Journal of Biological Chemistry》 258 (18): 11369–76. PMID 6309844. 
  • Hurley, JB; Simon, MI; Teplow, DB; Robishaw, JD; Gilman, AG (1984). “Homologies between signal transducing G proteins and ras gene products”. 《Science》 226 (4676): 860–2. doi:10.1126/science.6436980. PMID 6436980. 
  • Gilman, AG (1984). “G proteins and dual control of adenylate cyclase”. 《Cell》 36 (3): 577–9. doi:10.1016/0092-8674(84)90336-2. PMID 6321035. 
  • Bokoch, GM; Gilman, AG (1984). “Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin”. 《Cell》 39 (2 Pt 1): 301–8. doi:10.1016/0092-8674(84)90008-4. PMID 6094010. 
  • Harris, BA; Robishaw, JD; Mumby, SM; Gilman, AG (1985). “Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase”. 《Science》 229 (4719): 1274–7. doi:10.1126/science.3839937. PMID 3839937. 
  • Mattera, R; Graziano, MP; Yatani, A; Zhou, Z; Graf, R; Codina, J; Birnbaumer, L; Gilman, AG; Brown, AM (1989). “Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels”. 《Science》 243 (4892): 804–7. doi:10.1126/science.2536957. PMID 2536957. 
  • Krupinski, J; Coussen, F; Bakalyar, HA; Tang, WJ; Feinstein, PG; Orth, K; Slaughter, C; Reed, RR; Gilman, AG (1989). “Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure”. 《Science》 244 (4912): 1558–64. doi:10.1126/science.2472670. PMID 2472670. 
  • Tang, WJ; Gilman, AG (1991). “Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits”. 《Science》 254 (5037): 1500–3. doi:10.1126/science.1962211. PMID 1962211. 
  • Taussig, R; Iñiguez-Lluhi, JA; Gilman, AG (1993). “Inhibition of adenylyl cyclase by Gi alpha”. 《Science》 261 (5118): 218–21. doi:10.1126/science.8327893. PMID 8327893. 
  • Wickman, KD; Iñiguez-Lluhl, JA; Davenport, PA; Taussig, R; Krapivinsky, GB; Linder, ME; Gilman, AG; Clapham, DE (1994). “Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel”. 《Nature》 368 (6468): 255–7. doi:10.1038/368255a0. PMID 8145826. 
  • Coleman, D.; Berghuis, A.; Lee, E; Linder, M.; Gilman, A.; Sprang (1994). “Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis”. 《Science》 265 (5177): 1405–1412. doi:10.1126/science.8073283. PMID 8073283. 
  • Tang, WJ; Gilman, AG (1995). “Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin”. 《Science》 268 (5218): 1769–72. doi:10.1126/science.7792604. PMID 7792604. 
  • Mixon, MB; Lee, E; Coleman, DE; Berghuis, AM; Gilman, AG; Sprang, SR (1995). “Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis”. 《Science》 270 (5238): 954–60. doi:10.1126/science.270.5238.954. PMID 7481799. 
  • Wall, MA; Coleman, DE; Lee, E; Iñiguez-Lluhi, JA; Posner, BA; Gilman, AG; Sprang, SR (1995). “The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2”. 《Cell》 83 (6): 1047–58. doi:10.1016/0092-8674(95)90220-1. PMID 8521505. 
  • Berman, David M; Wilkie, Thomas M; Gilman, Alfred G (1996). “GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits”. 《Cell》 86 (3): 445–452. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726. 
  • Sunahara, RK; Tesmer, JJ; Gilman, AG; Sprang, SR (1997). “Crystal structure of the adenylyl cyclase activator Gsalpha”. 《Science》 278 (5345): 1943–7. doi:10.1126/science.278.5345.1943. PMID 9395396. 
  • Tesmer, JJ; Sunahara, RK; Gilman, AG; Sprang, SR (1997). “Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS”. 《Science》 278 (5345): 1907–16. doi:10.1126/science.278.5345.1907. PMID 9417641. 

참고 문헌 편집

각주 편집

  1. ↑ Lefkowitz, Robert J. (2016). “Alfred Goodman Gilman (1941–2015)”. 《Nature》 529 (7586): 284–284. doi:10.1038/529284a. 
  2. ↑ “The Nobel Prize in Physiology or Medicine 1994”. Nobel Media AB. 2016년 1월 22일에 확인함. 

외부 링크 편집

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