C5a 펩티데이스

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C5a 펩티데이스
C5a 펩티데이스
식별자
EC 번호	3.4.21.110
CAS 번호	100179-39-3
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IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB 구조	RCSB PDB PDBj PDBe PDBsum
PMC
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NCBI	proteins

C5a 펩티데이스(C5a peptidase, EC 3.4.21.110, streptococcal C5a peptidase, ScpA, ScpB, SCPA)는 세균 효소의 일종으로, 보체 조각인 C5a를 불활성화한다.^[1]^[2]^[3]^[4]^[5]^[6] 주된 절단 위치는 사람 C5a의 His⁶⁷-Lys⁶⁸, 그 외 절단 위치는 Ala⁵⁸-Ser⁵⁹가 있다.

매우 특이적인 기질 결합성을 보이며, 서브틸리신과 유사한 막연관 세린 펩티데이스이다.

참고 문헌 편집

↑ Wexler DE, Chenoweth DE, Cleary PP (December 1985). “Mechanism of action of the group A streptococcal C5a inactivator”. 《Proceedings of the National Academy of Sciences of the United States of America》 82 (23): 8144–8. doi:10.1073/pnas.82.23.8144. PMC 391459. PMID 3906656.
↑ Bohnsack JF, Mollison KW, Buko AM, Ashworth JC, Hill HR (February 1991). “Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus”. 《The Biochemical Journal》. 273 ( Pt 3) (3): 635–40. doi:10.1042/bj2730635. PMC 1149811. PMID 1996961.
↑ Cleary PP, Prahbu U, Dale JB, Wexler DE, Handley J (December 1992). “Streptococcal C5a peptidase is a highly specific endopeptidase”. 《Infection and Immunity》 60 (12): 5219–23. doi:10.1128/iai.60.12.5219-5223.1992. PMC 258300. PMID 1452354.
↑ Anderson ET, Wetherell MG, Winter LA, Olmsted SB, Cleary PP, Matsuka YV (October 2002). “Processing, stability, and kinetic parameters of C5a peptidase from Streptococcus pyogenes”. 《European Journal of Biochemistry》 269 (19): 4839–51. doi:10.1046/j.1432-1033.2002.03183.x. PMID 12354115.
↑ Stafslien DK, Cleary PP (June 2000). “Characterization of the streptococcal C5a peptidase using a C5a-green fluorescent protein fusion protein substrate”. 《Journal of Bacteriology》 182 (11): 3254–8. doi:10.1128/jb.182.11.3254-3258.2000. PMC 94514. PMID 10809707.
↑ Terao Y, Yamaguchi M, Hamada S, Kawabata S (May 2006). “Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils”. 《The Journal of Biological Chemistry》 281 (20): 14215–23. doi:10.1074/jbc.M513408200. PMID 16565520.

외부 링크 편집

의학주제표목 (MeSH)의 C5a+peptidase

[1] Wexler DE, Chenoweth DE, Cleary PP (December 1985). “Mechanism of action of the group A streptococcal C5a inactivator”. 《Proceedings of the National Academy of Sciences of the United States of America》 82 (23): 8144–8. doi:10.1073/pnas.82.23.8144. PMC 391459. PMID 3906656.

[2] Bohnsack JF, Mollison KW, Buko AM, Ashworth JC, Hill HR (February 1991). “Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus”. 《The Biochemical Journal》. 273 ( Pt 3) (3): 635–40. doi:10.1042/bj2730635. PMC 1149811. PMID 1996961.

[3] Cleary PP, Prahbu U, Dale JB, Wexler DE, Handley J (December 1992). “Streptococcal C5a peptidase is a highly specific endopeptidase”. 《Infection and Immunity》 60 (12): 5219–23. doi:10.1128/iai.60.12.5219-5223.1992. PMC 258300. PMID 1452354.

[4] Anderson ET, Wetherell MG, Winter LA, Olmsted SB, Cleary PP, Matsuka YV (October 2002). “Processing, stability, and kinetic parameters of C5a peptidase from Streptococcus pyogenes”. 《European Journal of Biochemistry》 269 (19): 4839–51. doi:10.1046/j.1432-1033.2002.03183.x. PMID 12354115.

[5] Stafslien DK, Cleary PP (June 2000). “Characterization of the streptococcal C5a peptidase using a C5a-green fluorescent protein fusion protein substrate”. 《Journal of Bacteriology》 182 (11): 3254–8. doi:10.1128/jb.182.11.3254-3258.2000. PMC 94514. PMID 10809707.

[6] Terao Y, Yamaguchi M, Hamada S, Kawabata S (May 2006). “Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils”. 《The Journal of Biological Chemistry》 281 (20): 14215–23. doi:10.1074/jbc.M513408200. PMID 16565520.

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