SNAI1
기능편집
초파리 배아 단백질 SNAI1은 아연집게 전사 억제자로 중배엽내의 외배엽유전자의 발현을 하향 조절한다. 이 유전자에 의해 암호화 된 핵단백질은 구조적으로 초파리의 SNAI1 단백질과 유사하다. 그리고 발생하는 배아에 있어 중배엽의 형성에 매우 중요하다 생각된다. 2번 염색체의 최소한 두 가지의 변형된 위유전자가 발견되었다.[2]
임상적 중요성편집
SNAI1 유전자는 E-캐드헤린의 CDH1유전자의 발현을 하향 조절하여 EMT(epithelial-mesenchymal transition)을 유발하여 유방암의 재발하게 함을 보여주었다.[3]
상호작용편집
더 읽어보기편집
- Twigg SR, Wilkie AO (1999). “Characterisation of the human snail (SNAI1) gene and exclusion as a major disease gene in craniosynostosis.”. 《Hum. Genet.》 105 (4): 320–6. PMID 10543399. doi:10.1007/s004390051108.
- Batlle E, Sancho E, Francí C; 외. (2000). “The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells.”. 《Nat. Cell Biol.》 2 (2): 84–9. PMID 10655587. doi:10.1038/35000034.
- Smith S, Metcalfe JA, Elgar G (2000). “Identification and analysis of two snail genes in the pufferfish (Fugu rubripes) and mapping of human SNA to 20q.”. 《Gene》 247 (1–2): 119–28. PMID 10773451. doi:10.1016/S0378-1119(00)00110-4.
- Okubo T, Truong TK, Yu B; 외. (2001). “Down-regulation of promoter 1.3 activity of the human aromatase gene in breast tissue by zinc-finger protein, snail (SnaH)”. 《Cancer Res.》 61 (4): 1338–46. PMID 11245431.
- Deloukas P, Matthews LH, Ashurst J; 외. (2002). “The DNA sequence and comparative analysis of human chromosome 20”. 《Nature》 414 (6866): 865–71. PMID 11780052. doi:10.1038/414865a.
- Blanco MJ, Moreno-Bueno G, Sarrio D; 외. (2002). “Correlation of Snail expression with histological grade and lymph node status in breast carcinomas”. 《Oncogene》 21 (20): 3241–6. PMID 12082640. doi:10.1038/sj.onc.1205416.
- Guaita S, Puig I, Franci C; 외. (2002). “Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression”. 《J. Biol. Chem.》 277 (42): 39209–16. PMID 12161443. doi:10.1074/jbc.M206400200.
- Strausberg RL, Feingold EA, Grouse LH; 외. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. 《Proc. Natl. Acad. Sci. U.S.A.》 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
- Yokoyama K, Kamata N, Fujimoto R; 외. (2003). “Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas”. 《Int. J. Oncol.》 22 (4): 891–8. PMID 12632084.
- Ikenouchi J, Matsuda M, Furuse M, Tsukita S (2004). “Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail”. 《J. Cell. Sci.》 116 (Pt 10): 1959–67. PMID 12668723. doi:10.1242/jcs.00389.
- Domínguez D, Montserrat-Sentís B, Virgós-Soler A; 외. (2003). “Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor”. 《Mol. Cell. Biol.》 23 (14): 5078–89. PMC 162233. PMID 12832491. doi:10.1128/MCB.23.14.5078-5089.2003.
- Imai T, Horiuchi A, Wang C; 외. (2003). “Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells”. 《Am. J. Pathol.》 163 (4): 1437–47. PMC 1868286. PMID 14507651. doi:10.1016/S0002-9440(10)63501-8.
- Miyoshi A, Kitajima Y, Sumi K; 외. (2004). “Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells”. 《Br. J. Cancer》 90 (6): 1265–73. PMC 2409652. PMID 15026811. doi:10.1038/sj.bjc.6601685.
- Ohkubo T, Ozawa M (2004). “The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation”. 《J. Cell. Sci.》 117 (Pt 9): 1675–85. PMID 15075229. doi:10.1242/jcs.01004.
- Barberà MJ, Puig I, Domínguez D; 외. (2004). “Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells”. 《Oncogene》 23 (44): 7345–54. PMID 15286702. doi:10.1038/sj.onc.1207990.
- Beausoleil SA, Jedrychowski M, Schwartz D; 외. (2004). “Large-scale characterization of HeLa cell nuclear phosphoproteins”. 《Proc. Natl. Acad. Sci. U.S.A.》 101 (33): 12130–5. PMC 514446. PMID 15302935. doi:10.1073/pnas.0404720101.
- Kajita M, McClinic KN, Wade PA (2004). “Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress”. 《Mol. Cell. Biol.》 24 (17): 7559–66. PMC 506998. PMID 15314165. doi:10.1128/MCB.24.17.7559-7566.2004.
- Zhou BP, Deng J, Xia W; 외. (2004). “Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition”. 《Nat. Cell Biol.》 6 (10): 931–40. PMID 15448698. doi:10.1038/ncb1173.
- Saito T, Oda Y, Kawaguchi K; 외. (2004). “E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma”. 《Oncogene》 23 (53): 8629–38. PMID 15467754. doi:10.1038/sj.onc.1207960.
각주편집
- ↑ Paznekas WA, Okajima K, Schertzer M, Wood S, Jabs EW (2000년 2월). “Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P)”. 《Genomics》 62 (1): 42–9. PMID 10585766. doi:10.1006/geno.1999.6010.
- ↑ 가 나 “Entrez Gene: SNAI1 snail homolog 1 (Drosophila)”.
- ↑ Davidson NE, Sukumar S (2005년 9월). “Of Snail, mice, and women”. 《Cancer Cell》 8 (3): 173–4. PMID 16169460. doi:10.1016/j.ccr.2005.08.006.
- ↑ 가 나 다 Wu Y, Evers BM, Zhou BP (2009년 1월). “Small C-terminal domain phosphatase enhances snail activity through dephosphorylation”. 《J. Biol. Chem.》 284 (1): 640–8. PMC 2610500. PMID 19004823. doi:10.1074/jbc.M806916200.