TOX

TOX
식별자
다른 이름	TOX, TOX1, thymocyte selection associated high mobility group box
외부 ID	OMIM: 606863 MGI: 2181659 HomoloGene: 8822 GeneCards: TOX
유전자 위치 (인간)
염색체	8번 염색체
끝	59,119,147 bp
유전자 위치 (쥐)
염색체	4번 염색체 (쥐)
끝	6,991,557 bp
RNA 발현 패턴
	최상위 발현
	내피세포; ; secondary oocyte; ; 가슴샘; ; ganglionic eminence; ; 안와전두피질; ; 랑게르한스섬; ; dorsolateral prefrontal cortex; ; 전전두엽피질; ; Brodmann area 9; ; jejunal mucosa;
	최상위 발현
	갈비뼈; ; 가슴샘; ; medial dorsal nucleus; ; 반지연골; ; female urethra; ; 보습코기관; ; medial geniculate nucleus; ; 구형낭; ; 유두체; ; 일차운동피질;
	추가 참조 발현 데이터
	; ;
	추가 참조 발현 데이터
유전자 온톨로지
분자 함수	DNA 결합; DNA-binding transcription factor activity, RNA polymerase II-specific;
세포 성분	세포핵;
생물학적 과정	lymphocyte differentiation; positive regulation of natural killer cell differentiation; lymph node development; Peyer's patch development; regulation of transcription by RNA polymerase II;
	출처: Amigo / QuickGO
동원체
	9760
	252838
	ENSG00000198846
	ENSMUSG00000041272
	O94900
	Q66JW3
	NM_014729
	NM_145711; NM_001377078; NM_001377079
	NP_055544
	NP_663757; NP_001364007; NP_001364008
	위키데이터
인간 보기/편집	쥐 보기/편집

TOX(Thymocyte selection-associated high mobility group box protein)는 TOX 유전자에 의해 인코딩되는 인간 단백질이다.^[5]^[6]^[7] TOX는 T세포 고갈을 몰아붙이며^[8]^[9] 선천 림프세포 발달의 역할을 한다.^[10]^[11]

각주 편집

↑ ^가 ^나 ^다 GRCh38: Ensembl release 89: ENSG00000198846 - 앙상블, May 2017
↑ ^가 ^나 ^다 GRCm38: Ensembl release 89: ENSMUSG00000041272 - 앙상블, May 2017
↑ “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, 외. (October 1998). “Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. 《DNA Research》 5 (5): 277–286. doi:10.1093/dnares/5.5.277. PMID 9872452.
↑ Wilkinson B, Chen JY, Han P, Rufner KM, Goularte OD, Kaye J (March 2002). “TOX: an HMG box protein implicated in the regulation of thymocyte selection”. 《Nature Immunology》 3 (3): 272–280. doi:10.1038/ni767. PMID 11850626. S2CID 19716719.
↑ “Entrez Gene: thymocyte selection-associated high mobility group box gene TOX”.
↑ Bordon Y (August 2019). “TOX for tired T cells”. 《Nature Reviews. Immunology》 19 (8): 476. doi:10.1038/s41577-019-0193-9. PMID 31243349.
↑ Ando M, Ito M, Srirat T, Kondo T, Yoshimura A (March 2020). “Memory T cell, exhaustion, and tumor immunity”. 《Immunological Medicine》 43 (1): 1–9. doi:10.1080/25785826.2019.1698261. PMID 31822213.
↑ Seehus CR, Kaye J (2015). “The Role of TOX in the Development of Innate Lymphoid Cells”. 《Mediators of Inflammation》 2015: 243868. doi:10.1155/2015/243868. PMC 4628649. PMID 26556952.
↑ Stokic-Trtica V, Diefenbach A, Klose CS (2020). “NK Cell Development in Times of Innate Lymphoid Cell Diversity”. 《Frontiers in Immunology》 (영어) 11: 813. doi:10.3389/fimmu.2020.00813. PMC 7360798. PMID 32733432.

[refGRCh38Ensembl-1] 가 ^나 ^다 GRCh38: Ensembl release 89: ENSG00000198846 - 앙상블, May 2017

[refGRCm38Ensembl-2] 가 ^나 ^다 GRCm38: Ensembl release 89: ENSMUSG00000041272 - 앙상블, May 2017

[3] “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[4] “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[pmid9872452-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, 외. (October 1998). “Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. 《DNA Research》 5 (5): 277–286. doi:10.1093/dnares/5.5.277. PMID 9872452.

[pmid11850626-6] Wilkinson B, Chen JY, Han P, Rufner KM, Goularte OD, Kaye J (March 2002). “TOX: an HMG box protein implicated in the regulation of thymocyte selection”. 《Nature Immunology》 3 (3): 272–280. doi:10.1038/ni767. PMID 11850626. S2CID 19716719.

[entrez_9760-7] “Entrez Gene: thymocyte selection-associated high mobility group box gene TOX”.

[:0-8] Bordon Y (August 2019). “TOX for tired T cells”. 《Nature Reviews. Immunology》 19 (8): 476. doi:10.1038/s41577-019-0193-9. PMID 31243349.

[:1-9] Ando M, Ito M, Srirat T, Kondo T, Yoshimura A (March 2020). “Memory T cell, exhaustion, and tumor immunity”. 《Immunological Medicine》 43 (1): 1–9. doi:10.1080/25785826.2019.1698261. PMID 31822213.

[:2-10] Seehus CR, Kaye J (2015). “The Role of TOX in the Development of Innate Lymphoid Cells”. 《Mediators of Inflammation》 2015: 243868. doi:10.1155/2015/243868. PMC 4628649. PMID 26556952.

[:3-11] Stokic-Trtica V, Diefenbach A, Klose CS (2020). “NK Cell Development in Times of Innate Lymphoid Cell Diversity”. 《Frontiers in Immunology》 (영어) 11: 813. doi:10.3389/fimmu.2020.00813. PMC 7360798. PMID 32733432.

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